What is an Atypical BSE?
نویسنده
چکیده
The number of cases of Bovine Spongiform Encephalopathy (BSE) in the United Kingdom (UK) and Europe has decreased during the last years. The disease is designated as Classical BSE (C-BSE) once the prion protein involved is very constant and has genetic identity. On the other hand, atypical cases have occurred in several countries, apparently without any relationship with contaminated feeding. Atypical cases, H or L-BSE can have involvement with the etiology of the known C-BSE, first diagnosed in the UK. With the control of C-BSE based on rigid control of feeding, the occurrence of atypical BSE may predominate in the future. In this hypothesis atypical BSE, probably a spontaneous encephalopathy of cattle, will be considered as Sporadic BSE in contrast with the C-BSE that could be nominated UK-BSE.
منابع مشابه
Detection and partial discrimination of atypical and classical bovine spongiform encephalopathies in cattle and primates using real-time quaking-induced conversion assay
The transmission of classical bovine spongiform encephalopathy (C-BSE) through contaminated meat product consumption is responsible for variant Creutzfeldt-Jakob disease (vCJD) in humans. More recent and atypical forms of BSE (L-BSE and H-BSE) have been identified in cattle since the C-BSE epidemic. Their low incidence and advanced age of onset are compatible with a sporadic origin, as are most...
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Two regulatory region polymorphisms in the prion gene of cattle have been reported to have an association with resistance to classical bovine spongiform encephalopathy (BSE). However, it is not known if this association also applies to other transmissible spongiform encephalopathies (TSE) in cattle. In this report, we compare the relationship between these 2 polymorphisms and resistance in catt...
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BACKGROUND Cattle with L-type (L-BSE) and H-type (H-BSE) atypical Bovine Spongiform encephalopathy (BSE) were identified in 2003 in Italy and France respectively before being identified in other countries worldwide. As of December 2011, around 60 atypical BSE cases have currently been reported in 13 countries, with over one third in France. While the epidemiology of classical BSE (C-BSE) has be...
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The significance of atypical bovine spongiform encephalopathies (BSE) in cattle for controlling the BSE epidemic is poorly understood. Here we report a case of atypical H-type BSE in a cow born after the implementation of the reinforced feed ban in Europe. This supports an etiology of H-type BSE unrelated to that of classical BSE.
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BACKGROUND Bovine spongiform encephalopathy (BSE) is a transmissible spongiform encephalopathy (TSE) of cattle. Classical BSE is associated with ingestion of BSE-contaminated feedstuffs. H- and L-type BSE, collectively known as atypical BSE, differ from classical BSE by displaying a different disease phenotype and they have not been linked to the consumption of contaminated feed. Interestingly,...
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